Phyllodes tumor

Phyllodes tumor is a rare, malignant growth of the breast cancer that develops rapidly. Read further to know more about the causes, symptoms, diagnosis and treatment of this cancerous condition.

What is Phyllodes Tumor?

It is a rare tumor which arises in the connective tissue of the breast instead of the epithelial tissue. Thus, it is also referred to as “Sarcoma”. It is also known by other names like:

  • Phylloides tumor
  • Cystosarcoma phyllodes
  • Cystosarscoma phylloides
  • Giant Fibroadenomas

This breast lump can be either malignant or benign. It is an extremely rare tumor and is believed to account for 1% of all breast cancers.

Causes of Phyllodes Tumor

There are various possible causes behind the occurrence of this tumor, such as:

Picture of Phyllodes tumor

Picture 1 – Phyllodes tumor

  • Family history
  • Early menarche
  • Late menopause
  • Problems with hormone therapy

Research also suggests that women who become mother at an older age are more prone to this tumor. For instance, a woman becoming mother after the age of 30 is twice more susceptible than one who gives birth at the age of 25.

Symptoms of Phyllodes Tumor

The common symptoms of this condition are:

Large breast lumps

The condition is primarily characterized by the formation of large masses on the periductal stromal cells of the breast. Initially, the lump is not painful. However, patients may experience pain in the later stages as the tumor grows in size.

Redness of breast

In some patients, the skin on the affected region of the breast turns red in color.

Rapid growth of tumor

Fast growth of this tumor is another notable characteristic of this condition. On an average, this type of tumor is found to grow larger by about 2-3 cm in a span of few weeks.

Development of ulcers or wounds

In extreme cases, an ulcer or wound may develop near the affected area.

It is noteworthy that these tumors mainly occurin menopausal women. In adolescent girls, a similar disorder, Fibroadenoma, is more common.

Stages of Phyllodes Tumor

Generally, all breast cancers are classified in four stages, from stage1-4. In case of Phyllodes growths, however, the classification is entirely different. Based on whether or not they are cancerous, these growths are distinguished into:

  • Benign phyllodes tumor – It is a harmless condition.
  • Malignant phyllodes tumor – As the name implies, it is a cancerous condition.

The lumps are distinguished on the basis of certain features like appearance, growth of stromal cells and the presence of epithelial cells.

Diagnosis of Phyllodes Tumor

These lumps are generally confused with Fibroadenomas, which makes their diagnosis a bit complicated. Tests like Mammogram and Breast ultrasound are not helpful either in differentiating these growths. Even the needle biopsy technique is useless as it gives ineffective sample cells. It requires a surgical biopsy to get a good sample for cells that can help in the diagnosis.

Image of Phyllodes tumor

Picture 2 – Phyllodes tumor Image

The various tests involved in the diagnosis of this abnormal mass are:

Physical examination of the breast

This involves detection of the lump in the breast. You can either self examine the breast by standing before a mirror or take the help of your doctor for the physical examination.

Mammogram

This test helps determine the exact location of a tumor and provides X-ray images of the breast. This tumor is manifested by some typical features, such as calcifications or development of a round mass with edges.

Ultrasound and MRI

This technique is employed to obtain sound wave images of the breast. MRI also provides further details about the tumor that helps in the surgical process.

Biopsy

This technique is used to take out sample cells from the affected part of the breast. There are two types of this process – Core Needle Biopsy and Excisional Biopsy. In Core Needle Biopsy, a needle is used to take the sample cells while in Excisional biopsy the entire tumor is removed. The sample tissue is examined for the confirmation of Phyllodes tumor. The tumor can be either benign or malignant. Each type has its unique traits. Benign tumors have distinct edges, contain epithelial cells and have stromal cells with a normal appearance. Malignant tumors, on the other hand, have edges that are not distinct. The stromal cells in these growths have an abnormal appearance. The epithelial cells, in these cancerous lumps, may be less or absent due to overgrowth of stromal cells.

Treatment of Phyllodes Tumor

The use of drugs is not much beneficial in the treatment of this type of tumor. Moreover, the effects of radiation and hormonal therapy are also limited. In case the tumor is in the benign stage, it can be removed by Lumpectomy. If the tumor is malignant, however, treatment involves use of Mastectomy. Wide local excision is another common method to treat malignant tumor.

If you suspect an abnormal lump in your breast, get in touch with your family physician on an immediate basis. Early diagnosis and treatment will help you avoid worsening of the condition and have it cured in the very early stages. With proper treatment, you can get back to health within a short time.

References:

http://en.wikipedia.org/wiki/Phyllodes_tumor

http://www.breastcancer.org/symptoms/types/phyllodes/diagnosis.jsp

http://phyllodestumor.net/

http://breastcancer.about.com/od/types/p/phyllodes_sa.htm

http://www.hopkinsmedicine.org/avon_foundation_breast_center/breast_cancers_other_conditions/phyllodes_tumors.html

Published on May 14th 2012 by  under Cancer.
Article was last reviewed on 14th May 2012.

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